Macnification is a Mac OS X application for organizing, editing, analyzing and annotating microscopic images, designed for ease of use. It is being developed by Orbicule.

Macnification uses Bio-Formats to read files in some formats, including Gatan DM3, ICS, ImagePro SEQ, ImagePro IPW, Metamorph STK, OME-TIFF and Zeiss LSM.