Version history
5.5.1 (2017 May 25)
File format improvements:
- CellH5
- fix for HDF5SymbolTableException when recycling an IFormatReader to reopen
another CellH5 file
- bug fix related to opening of subsets of CellH5 files, namely
openBytes(r, no, x, y, w, h) for y>0
- Zeiss CZI
- fix pyramid resolution indexing for pyramids of different depths
- fix for incorrect channel names and colors
- Zeiss AxioVision ZVI
- correct parsing of epoch for Zeiss TIFF and Zeiss ZVI
Bug fixes:
- Command line tools
- fix for java.lang. NegativeArraySizeException caused by incorrect dimensions
when using showinf via command line with options set to autoscale and crop
- Format tools
- fix for java.lang. IndexOutOfBoundsException when using getFilename with an
image containing multiple samples per pixel channels and a single effective channel
Updated build system:
- Autogen jobs
- fix for gen-meta-support to locate available org.openmicroscopy:ome-xml
sources from the Maven repository following the decoupling of the model components
- FileHandleTest
- exclude JHDF5 native libraries from FileHandleTest to enable CellH5 files to be
included in daily tests
Documentation improvements:
- added a new example file for reading and writing of XZ and YZ orthogonal planes
5.5.0 (2017 May 8)
New file formats:
- Olympus OIR
- added support for Olympus .oir data (funded by a
partnership between Glencoe Software and OLYMPUS EUROPA SE & Co. KG)
- PerkinElmer Columbus
-
File format improvements:
- Andor Bio-Imaging Division (ABD) TIFF
- fixed acquisition date format from MM/dd/yyyy to dd/MM/yyyy
- Nikon NIS-Elements ND2
- corrected logic used to determined PixelType by parsing uiBpc tags
- Hamamatsu ndpi
- improved handling of channels in NDPIS datasets (thanks to Manuel Stritt)
- Imspector OBF
- fix for SAXParseException when description field in metadata is empty
Documentation improvements:
- added links to public sample files for Cellomics
- added links to public sample files for InCell 3000
5.4.1 (2017 April 13)
File format improvements:
- MIAS (Maia Scientific)
- added a fix for a possible exception when image files are not found under
channel-specific subdirectories
- BD Pathway
- added fix to check if Experiment.exp is a directory or an experiment file
- Imspector OBF
- enabled forward compatibility for future versions, as the OBF format is backwards
compatible (thanks to Bjoern Thiel)
Documentation improvements:
- updated external homepage link for FocalPoint
- removed Imago from list of visualization and analysis applications as it is no
longer available from the Mayachitra website
- added links to public sample files for Hamamatsu NDPI and Hamamatsu VMS
- listed OpenSlide as available software for supported formats
- added a new developer page detailing in-memory reading and writing
- updated the Bio-Formats API versioning policy, which now follows strict
semantic versioning
- a new options page has been added, detailing the usage of configurable format-specific
options for readers and writers. Links to the available options are also included under
the relevant supported formats
5.4.0 (2017 March 21)
File format improvements:
- DICOM
- added support for DICOMDIR files, which allow multiple DICOM files in a
single directory to be opened as a single dataset
- plane position values for values X, Y and Z are now being set in OME-XML
- correctly read the physical size X and Y values based on the available
specification
- Nikon NIS-Elements ND2
- performance improvements based on reading chunkmap. Processing of the
chunkmap can be disabled via the MetadataOptions API using the boolean
option nativend2.chunkmap. For ImageJ users this option can be
accessed via a checkbox in the Nikon ND2 section of the Bio-Formats
configuration dialog
(thanks to Christian Sachs)
- OME-TIFF
- added an option to save an OME-TIFF dataset as a binary TIFF and
companion XML. This can be used via the bfconvert command line tool by
setting the value of option ometiff.companion to the name of the
companion file to use. For example bfconvert -option ometiff.companion
outputFile.companion.ome inputFile.tiff outputFile.ome.tiff
- CellVoyager
- metadata fixes specifically the naming of plates. Additional refactoring
of the reader for general maintainability
- Gatan Digital Micrograph
- previously missing Image-Instrument reference has been added to OME-XML
- TiffSaver
- ensure open resources are closed under all possible scenarios
- Zeiss CZI
- improved performance of large uncompressed images. When tiles from a
large uncompressed image with no internal tiling are requested, only the
specific tile specified in the call to openBytes is read from disk,
instead of the entire image being read and then copied
- Zeiss AxioVision ZVI (Zeiss Vision Image)
- ensure that the bitsPerPixel field is always set to match the final
pixel type, and populate any channel colors that were parsed in the
metadata. The bits per pixel update should only affect uint16 or
int16 files where the acquisition bit depth is not a multiple of 8,
and the RGB channel count is greater than 1
Updated build system:
- updated dependency for NetCDF to 4.3.22
- updated copyright headers from 2016 to 2017 and reviewed and fixed any incorrect
header descriptions
- documentation has been migrated to use .rst file format for Sphinx files
- reviewed and cleaned up warnings such as unused variables and imports
- added CellVoyager datasets to automated testing via continuous integration
- unified the semantics for creating temporary directories within unit tests
Documentation improvements:
- fixed link for PerkinElmer UltraVIEW system
- fixed links for NIfTI public specification and data sets
- available software for Hamamatsu ndpi has been updated from NDP.view to NDP.view2
5.3.4 (2017 February 21)
Bug fixes:
- ImageJ
- fix for a NullPointerException when exporting images that were not opened via
the Bio-Formats importer, and thus do not have a complete OMEXMLMetadata store
- Java 1.9
- fix compile and runtime errors to enable building with Java 1.9
- ECAT7
- update to add support for different versions of ECAT7 files (thanks to Torsten Stöter)
Updated build system:
- updated dependency for ome-model in the POM to
version 5.4.0. This allows for improved ROI handling by enabling support for Shape
objects with Transform attributes. OME-XML schema version remains unchanged as
OME schema 2016-06
Documentation improvements:
- new public sample files added for ECAT7 (thanks to Torsten Stöter)
- new public sample files added for Leica LIF (thanks to Michael Goelzer)
- new specification document (Version 3.2) for Leica LIF
- updated links to OMERO documentation as a result of decoupling
5.3.3 (2017 February 2)
Bug fixes:
- ImageJ
- fix for issue when exporting from an ImagePlus that represents signed
data. The pixel type will now remain unchanged as will the pixel values
which had previously been scaled incorrectly
- Command line tools
- fix for java.lang.IllegalArgumentException when using bfconvert via command line
with option set to only convert a single time-point, channel or Z section
- Tiff writing
- using TiffWriter to write tiled images now supports the writing of
BigTIFF datasets
File format fixes:
- Applied Precision CellWorX
- fix to now display the correct plate name and dimensions
- NIFTI
- a few fixes for problems with byte alignment when reading non-core
metadata from NIFTI headers
- Leica LIF
- added support for timestamps of LIF files created with LAS AF 3.1 or
newer. In the case of a halted acquisition only non-null timestamps are
stored in the OME metadata (thanks to Michael Goelzer)
- the physical pixel height and width were incorrectly calculated by
dividing by the number of pixels. This has now been corrected to match
the official Leica LIF specification documents by dividing by the number
of pixels minus one (thanks to Michael Goelzer)
- for backwards compatibility an option to preserve pre-5.3.3 physical sizes
has been added. This can be set either via command line tools, through
the API with the loci.formats.in.DynamicMetadataOptions class, or in the Bio-Formats
plugin configuration in ImageJ
- Improvision TIFF
- channel colors are now being read and if present set correctly in image metadata
- MetaMorph
- fix for java.lang.OutOfMemoryError exceptions when reading large Metamorph TIFF plates
Updated build system:
- version history file added to MATLAB bundle as NEWS.rst
- increased TiffWriter test coverage
- added test coverage framework for command line tools including new ImageConverterTest
Documentation improvements:
- improved documentation and new examples for using tiled writing
- updated developer documentation for use of Bio-Formats as a Maven, Gradle
or Ivy dependency
- documentation for Leica LIF bug fixes and use of backward compatibility options
- fixes for a number of broken links
5.3.2 (2017 January 9)
Bug fixes:
- ImageJ
- fixed race condition when opening multiple series from a dataset, as
introduced by thumbnail loading changes in 5.3.0
- updated thumbnail generation to be faster for datasets containing an
image pyramid
- Metamorph
- updated to read the refractive index and set RefractiveIndex on
ObjectiveSettings in the generated OME-XML (thanks to Marc Bruce)
- Metamorph TIFF
- fixed Z and channel dimension counts when each channel has a unique Z position
- updated to read the emission wavelength and set EmissionWavelength on
LightSourceSettings in the generated OME-XML
- QuickTime
- fixed incorrect image data when reading of tiles from single channel files
- file grouping
- fixed handling of loci.formats.in.MetadataOptions objects by the
loci.formats.FileStitcher reader
Documentation improvements:
- fixed extensions listed for Zeiss TIFF
- simplified markdown for creating tables
5.3.1 (2016 December 19)
File format fixes:
- TIFF
- fixed invalid IFD values when writing TIFF or OME-TIFF files with
Bio-Formats 5.3.0. This bug affected the writing of TIFF and OME-TIFF
via client code using loci.formats.TiffWriter, converting to a TIFF
or OME-TIFF using ‘bfconvert’ command line tool or exporting to TIFF or
OME-TIFF using ImageJ/FIJI Bio-Formats exporter.
5.3.0 (2016 December 12)
New features/API:
added support for JPEG-XR compressed CZI data (funded by a
partnership between Glencoe Software and ZEISS), adding ‘ome:jxrlib’ as a new dependency
of Bio-Formats
- improved tile-based image writing
- added new methods to the loci.formats.IFormatWriter interface
allowing to set and retrieve the tile along the X and Y dimensions
- added default implementations to the loci.formats.FormatWriter
abstract class defaulting to the entire image width/height
- added functionality to loci.formats.TiffWriter adding support for
tiled images writing for TIFF and derived formats like OME-TIFF
- added developer documentation and samples for tiled reading/writing
added a new MetadataOptions implementation supporting arbitrary key/value
pairs
updated the display command line utility to support passing key/value
options using showinf -option
added two options to the CZI reader to disable autostitching and exclude
pyramid file attachments. Added new checkboxes to the CZI configuration
interface of the ImageJ plugin to activate these options
Bug fixes/deprecations:
Component architecture changes/decoupling:
- removed formats-common component - now decoupled to the new
ome/ome-common-java GitHub repository
and consumed as ‘org.openmicroscopy:ome-common’ artifact from Maven
Central
- removed ome-poi component - now decoupled to the new
ome/ome-poi GitHub repository
and consumed as ‘org.openmicroscopy:ome-poi’ artifact from Maven Central
- removed specification, xsd-fu and ome-xml components - now decoupled to the
new ome/ome-model GitHub repository
and consumed as ‘org.openmicroscopy:{specification,ome-xml}’
artifacts from Maven Central
- removed mdbtools component - now decoupled to the new
ome/ome-mdbtools GitHub repository
and consumed as ‘org.openmicroscopy:ome-mdbtools’ artifact from Maven
Central
- removed stubs components - now decoupled to the new
ome/ome-stubs GitHub repository and
consumed as ‘org.openmicroscopy:{lwf-stubs,mipav-stubs}’ artifacts from
Maven Central
- removed metakit component - now decoupled to the new
ome/ome-metakit GitHub repository
and consumed as ‘org.openmicroscopy:metakit’ artifacts from
Maven Central
- updated developer documentation for the decoupled components
Updated build system:
- dropped embedded JARs and now use the Maven Ant Tasks plugin to unify the
dependencies using the POM
- improved Ant JAR and bundle target
- dropped deprecated osgi targets, OME Tools bundle and ome-jxr component
- removed PDF generation from the docs-sphinx target
- added version number to Javadoc zip bundle name
- migrated unit tests out of test-suite into formats-bsd
- fixed test-suite targets, paths and symlink handling
- fixed test-metadata and migrated it into test-suite
- fixed mismatch between ND2HandlerTest package and location
- cleaned up test-build to remove obsolete and decoupled components
and folders
- simplified Travis build
- POM repositories clean-up to reduce complexity and use Maven Central as the
first location to look for dependencies
- now storing all versions in the top-level POM
- updated build versioning from Maven by unified versioning strategy,
reviewing meta information stored in the manifests of each JAR and
introspecting this information in the FormatTools API to retrieve
version and revision numbers
- updated developer documentation on updated build system
5.2.4 (2016 October 18)
Java bug fixes:
- OME-TIFF
- fixed regression when populating plane metadata
- CZI
- populated series metadata with the scene/position information
5.2.3 (2016 October 5)
Java bug fixes:
- CZI
- fixed imageCount for RGB images
- ICS writing
- fixed ordering of image dimensions
- DeltaVision
- fixed reading of large time dimensions
Command-line tools improvements:
- bftools.zip now includes the version history as NEWS.rst
(thanks to Gerhard Burger)
Code clean-up/improvements:
- switched to String.indexOf(int) in GPL-licensed reader code so that a
simpler library method can be used
- strings now extended with characters where possible
- completed deprecation of DataTools.sanitizeDouble()
- deprecated unused OSGi and ome-tools bundle build targets
OME-XML changes/improvements:
- bumped schema version number to 2 (schema namespace left unchanged)
- added acquisition modes BrightField, SweptFieldConfocal and SPIM
- added parsing for Laser Scan Confocal and Swept Field Confocal
Documentation improvements:
- documented versioning policy
- clarified supported versions for Micro-Manager and Olympus ScanR files
5.2.2 (2016 September 13)
Java bug fixes and improvements:
fixed a regression in which the DataTools number parsing API would not be
thread-safe anymore
- InCell
- improved handling of Analyzer 2000 datasets to find TIFF files
- FV1000
- fixed preview names ordering
- OME-TIFF
- enabled all BigTIFF extensions
various code cleanup across the Java code
added test coverage for all example codes in the developer documentations
added tests covering the semantics of the INI parser
ImageJ bug fixes and improvements:
- fixed a bug in ImageJ when swapping dimensions of an image with multiple
series of different dimensions
- added an option to the exporter to pad filename indexes with zeros
Command-line tools improvements:
- allowed the binaries to be symlinked (thanks to Gerhard Burger)
- added an option to bfconvert to pad filename indexes with zeros
5.2.1 (2016 August 25)
Java bug fixes:
- Zeiss CZI
- fixed NumberFormatException when the position object is not null but the
values of child are null
- SimplePCI
- made IniParser less stringent to allow reading of imperfectly formatted
TIFF description headers
fixed stitching of file patterns in ImageJ to remove duplication of
directory names in the file path
added an option to bfconvert to allow creation of OME-TIFF without lookup
tables
addition of MetadataOnly elements containing no BinData or TiffData now
handled via MetadataTools API in ImageInfo
example code in developer docs is now tested via a new Maven module
5.2.0 (2016 August 18)
Java format support improvements are listed below.
†Denotes a major breaking change to the reader (typically modification of core
metadata). Code changes or re-import may be necessary in ImageJ/FIJI and
OMERO.
Top-level Bio-Formats API changes:
Java 1.7 is now the minimum supported version
the native-lib-loader dependency has been bumped to version 2.1.4
the xalan dependency has been bumped to version 2.7.2
all the ome.jxr classes have been deprecated to make clear that there is no
JPEG-XR support implemented in Bio-Formats as yet
- the DataTools API has been extended to add a number of utility functions to:
- account for decimal separators in different locales
- parse a String into Double, Float, Integer etc
- handle NumberFormatException thrown when parsing Unit tests
the Logging API has been updated to respect logging frameworks
(log4j/logback) initialized via a binding-specific configuration file and
to prevent DebugTools.enableLogging(String) from overriding initialized
logger levels (see Logging for more information)
helper methods have been added to FormatTools allowing a stage position to
be formatted from an input Double and an input unit
the Formats API has also been updated to add a new validate property to
MetadataOptions and support for MetadataOptions has been moved to
FormatHandler level to allow it to be used by both Readers and Writers
initial work on Reader discoverability
extended the ClassList API to allow the readers.txt configuration
file to be annotated using key/value pairs to mark optional Readers and
specify additional per-Reader options
Other general improvements include:
improved performance of getUsedFiles
fixes for FilePatternBlock, AxisGuesser, FilePattern
fixes for the detection of CSV pattern blocks by FilePatternBlock
bioformats_package.jar now includes bio-formats-tools as a
dependency so ImageConverter, ImageFaker and ImageInfo classes
are included in the bundle
the JACE C++ implementation has been decoupled as it does not function with
Java 1.8 (see legacy repo)
- ImageJ fixes
- to allow reader delegation when a legacy reader is enabled
but not working
- to allow ROIs to be imported to the ImageJ ROI manager or added to a new
overlay
- MATLAB fixes
- improved integration with Octave (thanks to Carnë Draug)
- added logging initialization
- Command-line tools fixes
- upgrade check no longer run when passing -version
- common methods refactoring
- showinf improvements to preload format
- tiffcomment now warns that it requires an ImageDescription tag to be
present in the TIFF file
added many automated tests and improved FakeReader testing framework
- documentation improvements include:
- clarifying status of legacy Quicktime and ND2 readers
- noting that the Gatan reader does not currently support stacks
- more Java examples added to the developer documentation
- new units page for developers
The Data Model version 2016-06 has been released to introduce
Folders,
and to simplify both the graphical aspects of the model and code generation.
Full details are available in the
OME Model and Formats Documentation.
OME-XML changes include:
Map is now a complexType rather than an element and MapPairs has been
dropped
extended enum metadata has been introduced to better support units
Shape and LightSource are now complexTypes rather than elements
BinData has been added to code generation to handle raw binary data
- various code generation improvements to:
- simplify and standardize the generation process
- remove a number of hard-coded exceptional cases allowing for easier
maintenance and growth
- allow for genuine abstract model types and enable C++ model
implementation
updated OME-XML and OME-TIFF public sample files
The Bio-Formats C++ native implementation has been decoupled from
the Java codebase and will be released as
OME-Files C++ from now
on, with the exception of OME-XML which is still within Bio-Formats at present
(there is a plan to decouple both the Java and the C++ versions of OME-XML in
future).
The following components have had their licensing updated to Simplified
(2-clause) BSD:
- XSL transforms
- specification code
- xsd-fu Python code
5.1.10 (2016 May 9)
Java bug fixes:
- fixed warnings being thrown for ImageJ and other non-FIJI users on Windows
(these warnings were triggered by the removal of the 3i Slidebook DLLs from
the source code repository in Bio-Formats 5.1.9 and should now only be
triggered when opening Slidebook files without the update site enabled -
http://www.openmicroscopy.org/info/slidebook)
- a fix in the ImageJ plugin for files grouped using the “Dimensions” option
- a fix for writing TIFF files in tiles
5.1.9 (2016 April 14)
- Java bug fixes, including:
- SDT
- fixed width padding calculation for single-pixel image
- Deltavision
- fixed the parsing of the new date format
- added support for parsing and storing the working distance in native units
- Micromanager
- cleaned up JSON metadata parsing
- Olympus Fluoview
- fixed null pointer exceptions while parsing metadata
- Leica LIF
- fixed large multi-tiled files from having incorrect plane offsets after the 2GB mark
- EM formats (MRC and Spider)
- added native length support for EM readers
- Gatan
- fixed erroneous metadata parsing
- added support for parsing and storing the physical sizes in native units
- OME-TIFF
- improved handling of OME-TIFF multi-file fileset’s with partial metadata blocks
- Nikon ND2
- fixed the parsing of emission wavelength
- Olympus CellR (APL)
- fixed multiple parsing issues with the mtb file
- SlideBook
-
- Zeiss CZI
- fixed parsing of files with multiple mosaics and positions
- Documentation updates, including:
- improved documentation for the export of BigTIFFs in ImageJ
- C++:
-
5.1.8 (2016 February 15)
- Java bug fixes, including:
-
- Documentation updates, including:
- updated format pages to include links to example data
- clarified description of Qu for MATLAB (thanks to Carnë Draug)
- added installation instructions for Octave (thanks to Carnë Draug)
- C++:
- Bugfixes to the OME-TIFF writer to correct use of the metadata store with
multiple series
- Ensure file and writer state consistency upon close failure
5.1.7 (2015 December 7)
- Java bug fixes, including:
-
- Documentation updates, including:
- updated MapAnnotation example to show linkage of annotations to images
- C++:
- no changes, released to keep version numbers in sync with Bio-Formats Java
5.1.6 (2015 November 16)
- Java bug fixes, including:
- Updated to use native units for following formats:
- IMOD
- Analyze
- Unisoku
- Olympus CellR (APL)
- Metamorph TIFF
- fixed handling of multi-line descriptions
- added support for dual camera acquisitions
- Zeiss LMS
- fixed exception in type detection
- Zeiss CZI
- fixed detection of line scan Airyscan data
- Slidebook
- fixed calculation of physical Z size
- ImageJ plugins
- fixed handling of non-default units
- fixed setting of preferences via macros
- Automated testing
- fixed handling of non-default units for physical sizes and timings
- C++ changes, including:
- allow relocatable installation on Windows
- reduce time required for debug builds
- Documentation updates, including:
- addition of “Multiple Images” column to the supported formats table
- addition of a MapAnnotation example
5.1.4 (2015 September 7)
- Bug fixes, including:
- Command line tools
- fixed display of usage information
- Automated testing
- fixed problems with symlinked data on Windows
- added unit tests for checking physical pixel size creation
- Cellomics
- fixed reading of sparse plates
- SlideBook
- fixed a few lingering issues with native library packaging
- SimplePCI/HCImage TIFF
- fixed bit depth parsing for files from newer versions of HCImage
- SimplePCI/HCImage .cxd
- fixed image dimensions to allow for extra padding bytes
- Leica LIF
- improved reading of image descriptions
- ICS
- fixed to use correct units for timestamps and physical pixel sizes
- MicroManager
- fixed to use correct units for timestamps
- Gatan .dm3/.dm4
- fixed problems with reading double-precision metadata values
- Hamamatsu NDPI
- fixed reading of mask images
- Leica .lei
- fixed reading of bit depth and endianness for datasets that were modified after
acquisition
- FEI TIFF
- updated to read metadata from files produced by FEI Titan systems
- QuickTime
- fixed to handle planes with no stored pixels
- Leica .scn
- fixed reading of files that contain fewer images than expected
- Zeiss .czi
- fixed channel colors when an alpha value is not recorded
- fixed handling of pre-stitched image tiles
- SDT
- added support for Zip-compressed images
- Nikon .nd2
- fixed to read image dimensions from new non-XML metadata
- OME-XML
- fixed writing of integer metadata values
- Native C++ updates:
- completed support for building on Windows
- Documentation updates, including:
- updated instructions for running automated data tests
- clarified JVM versions currently supported
5.1.3 (2015 July 21)
- Native C++ updates:
- Added cmake superbuild to build core dependencies (zlib, bzip2, png, icu, xerces, boost)
- Progress on support for Windows
- Bug fixes, including:
-
- Documentation improvements, including:
- updated instructions for writing a new file format reader
- updated usage information for command line tools
- new Javadocs for the MetadataStore and MetadataRetrieve interfaces
5.1.2 (2015 May 28)
Added OME-TIFF writing support to the native C++ implementation
OME-TIFF export: switch to BigTIFF if .ome.tf2, .ome.tf8, or .ome.btf
extensions are used
Improved MATLAB developer documentation
Added SlideBook reader that uses the SDK from 3I (thanks to Richard Myers
and 3I - Intelligent Imaging Innovations)
Preliminary work to make MATLAB toolbox work with Octave
- Many bug fixes, including:
- ImageJ
- fixed regression in getPlanePosition* macro extension methods
- fixed display of composite color virtual stacks
- Nikon ND2
- improved parsing of plane position and timestamp data
- TIFF
- reduced memory required to read color lookup tables
- Zeiss LSM
- improved parsing of 16-bit color lookup tables
- Zeiss CZI
- fixed ordering of original metadata table
- fixed reading of large pre-stitched tiled images
- AIM
- fixed handling of truncated files
- Metamorph/MetaXpress TIFF
- improved UIC1 metadata tag parsing
5.1.1 (2015 April 28)
Add TIFF writing support to the native C++ implementation
Fixed remaining functional differences between Windows and Mac/Linux
Improved performance of ImageJ plugin when working with ROIs
TIFF export: switch to BigTIFF if .tf2, .tf8, or .btf extensions are used
- Many bug fixes, including:
-
5.1.0 (2015 April 2)
Improvements to performance with network file systems
Improvements to developer documentation
Initial version of native C++ implementation
Improved support for opening and saving ROI data with ImageJ
Added support for CellH5 data (thanks to Christoph Sommer)
Added support for Perkin Elmer Nuance data (thanks to Lee Kamentsky)
Added support for Amnis FlowSight data (thanks to Lee Kamentsky and Sebastien Simard)
Added support for Veeco AFM data
Added support for Zeiss .lms data (not to be confused with .lsm)
Added support for I2I data
Added support for writing Vaa3D data (thanks to Brian Long)
Updated to OME schema 2015-01
Update RandomAccessInputStream and RandomAccessOutputStream to read and write bits
- Many bug fixes, including:
-
5.0.8 (2015 February 10)
- No changes - release to keep version numbers in sync with OMERO
5.0.7 (2015 February 5)
- Several bug fixes, including:
- ND filter parsing for DeltaVision
- Timepoint count and original metadata parsing for Metamorph
- Build issues when Genshi or Git are missing
- LZW image decoding
5.0.6 (2014 November 11)
- Several bug fixes, including:
- Pixel sign for DICOM images
- Image dimensions for Zeiss CZI and Nikon ND2
- Support for Leica LIF files produced by LAS AF 4.0 and later
5.0.5 (2014 September 23)
- Documentation improvements
- Support for non-spectral Prairie 5.2 datasets
5.0.4 (2014 September 3)
- Fix compile and runtime errors under Java 1.8
- Improvements to Nikon .nd2 metadata parsing
- Added support for PicoQuant .bin files (thanks to Ian Munro)
5.0.2 (2014 May 28)
Many bug fixes for Zeiss .czi files
- Several other bug fixes, including:
- Gatan .dm3 units and step count parsing
- Imspector .msr 5D image support
- DICOM reading of nested tags
Update native-lib-loader version (to 2.0.1)
Updates and improvements to user documentation
5.0.1 (2014 Apr 7)
Added image pyramid support for CellSens .vsi data
- Several bug fixes, including:
- Woolz import into OMERO
- Cellomics file name parsing (thanks to Lee Kamentsky)
- Olympus FV1000 timestamp support (thanks to Lewis Kraft and Patrick Riley)
- (A)PNG large image support
- Zeiss .czi dimension detection for SPIM datasets
Performance improvements for Becker & Hickl .sdt file reading
(thanks to Ian Munro)
Performance improvements to directory listing over NFS
Update slf4j and logback versions (to 1.7.6 and 1.1.1 respectively)
Update jgoodies-forms version (to 1.7.2)
5.0.0 (2014 Feb 25)
- New bundled ‘bioformats_package.jar’ for ImageJ
- Now uses logback as the slf4j binding by default
- Updated component names, .jar file names, and Maven artifact names
- Fixed support for Becker & Hickl .sdt files with multiple blocks
- Fixed tiling support for TIFF, Hamamatsu .ndpi, JPEG, and Zeiss .czi files
- Improved continuous integration testing
- Updated command line documentation
5.0.0-RC1 (2013 Dec 19)
Updated Maven build system and launched new Artifactory repository
(http://artifacts.openmicroscopy.org)
- Added support for:
-
Added support for populating and parsing ModuloAlong{Z, C, T} annotations
for FLIM/SPIM data
Updated netCDF and slf4j version requirements - netCDF 4.3.19 and
slf4j 1.7.2 are now required
Updated and improved MATLAB users and
developers documentation
Many bug fixes including for Nikon ND2, Zeiss CZI, and CellWorX formats
5.0.0-beta1 (2013 June 20)
Updated to 2013-06 OME-XML schema
Improved the performance in tiled formats
Added caching of Reader metadata using http://code.google.com/p/kryo/
- Added support for:
-
- Many bug fixes, including:
- Add ZEN 2012/Lightsheet support to Zeiss CZI
- Improved testing of autogenerated code
- Moved OME-XML specification into Bio-Formats repository
4.4.10 (2014 Jan 15)
- Bug fixes including CellWorx, Metamorph and Zeiss CZI
- Updates to MATLAB documentation
4.4.9 (2013 Oct 16)
- Many bug fixes including improvements to support for ND2 format
- Java 1.6 is now the minimum supported version; Java 1.5 is no longer
supported
4.4.8 (2013 May 2)
- No changes - release to keep version numbers in sync with OMERO
4.4.7 (2013 April 25)
- Many bug fixes to improve support for more than 20 formats
- Improved export to multi-file datasets
- Now uses slf4j for logging rather than using log4j directly, enabling other
logging implementations to be used, for example when Bio-Formats is used as
a component in other software using a different logging system.
4.4.6 (2013 February 11)
- Many bug fixes
- Further documentation improvements
4.4.4 (2012 September 24)
4.4.2 (2012 August 22)
- Security fix for OMERO plugins for ImageJ
4.4.1 (2012 July 20)
- Fix a bug that prevented BigTIFF files from being read
- Fix a bug that prevented PerkinElmer .flex files from importing into OMERO
4.4.0 (2012 July 13)
Many, many bug fixes
- Added support for:
- .nd2 files from Nikon Elements version 4
- PerkinElmer Operetta data
- MJPEG-compressed AVIs
- MicroManager datasets with multiple positions
- Zeiss CZI data
- IMOD data
4.3.3 (2011 October 18)
- Many bug fixes, including:
- Speed improvements to HCImage/SimplePCI and Zeiss ZVI files
- Reduce memory required by Leica LIF reader
- More accurately populate metadata for Prairie TIFF datasets
- Various fixes to improve the security of the OMERO plugin for ImageJ
- Better dimension detection for Bruker MRI datasets
- Better thumbnail generation for histology (SVS, NDPI) datasets
- Fix stage position parsing for Metamorph TIFF datasets
- Correctly populate the channel name for PerkinElmer Flex files
4.3.2 (2011 September 15)
- Many bug fixes, including:
- Better support for Volocity datasets that contain compressed data
- More accurate parsing of ICS metadata
- More accurate parsing of cellSens .vsi files
- Added support for a few new formats
- .inr
- Canon DNG
- Hitachi S-4800
- Kodak .bip
- JPX
- Volocity Library Clipping (.acff)
- Bruker MRI
Updated Zeiss LSM reader to parse application tags
Various performance improvements, particularly for reading/writing TIFFs
Updated OMERO ImageJ plugin to work with OMERO 4.3.x
4.3.1 (2011 July 8)
- Several bug fixes, including:
- Fixes for multi-position DeltaVision files
- Fixes for MicroManager 1.4 data
- Fixes for 12 and 14-bit JPEG-2000 data
- Various fixes for reading Volocity .mvd2 datasets
Added various options to the ‘showinf’ and ‘bfconvert’ command line tools
Added better tests for OME-XML backwards compatibility
Added the ability to roughly stitch tiles in a multi-position dataset
4.3.0 (2011 June 14)
- Many bug fixes, including:
- Many fixes for reading and writing sub-images
- Fixes for stage position parsing in the Zeiss formats
- File type detection fixes
Updated JPEG-2000 reading and writing support to be more flexible
- Added support for 9 new formats:
- InCell 3000
- Trestle
- Hamamatsu .ndpi
- Hamamatsu VMS
- SPIDER
- Volocity .mvd2
- Olympus SIS TIFF
- IMAGIC
- cellSens VSI
Updated to 2011-06 OME-XML schema
Minor speed improvements in many formats
Switched version control system from SVN to Git
Moved all Trac tickets into the OME Trac: https://trac.openmicroscopy.org
Improvements to testing frameworks
Added Maven build system as an alternative to the existing Ant build system
Added pre-compiled C++ bindings to the download page
4.2.2 (2010 December 6)
- Several bug fixes, notably:
- Metadata parsing fixes for Zeiss LSM, Metamorph STK, and FV1000
- Prevented leaked file handles when exporting to TIFF/OME-TIFF
- Fixed how BufferedImages are converted to byte arrays
Proper support for OME-XML XML annotations
Added support for SCANCO Medical .aim files
Minor improvements to ImageJ plugins
Added support for reading JPEG-compressed AVI files
4.2.1 (2010 November 12)
Many, many bug fixes
- Added support for 7 new formats:
- CellWorX .pnl
- ECAT7
- Varian FDF
- Perkin Elmer Densitometer
- FEI TIFF
- Compix/SimplePCI TIFF
- Nikon Elements TIFF
Updated Zeiss LSM metadata parsing, with generous assistance from Zeiss, FMI, and MPI-CBG
Lots of work to ensure that converted OME-XML validates
Improved file stitching functionality; non-numerical file patterns and limited regular expression-style patterns are now supported
4.2.0 (2010 July 9)
- Fixed many, many bugs in all aspects of Bio-Formats
- Reworked ImageJ plugins to be more user- and developer-friendly
- Added many new unit tests
- Added support for approximately 25 new file formats, primarily in the SPM domain
- Rewrote underlying I/O infrastructure to be thread-safe and based on Java NIO
- Rewrote OME-XML parsing/generation layer; OME-XML 2010-06 is now supported
- Improved support for exporting large images
- Improved support for exporting to multiple files
- Updated logging infrastructure to use slf4j and log4j
4.1.1 (2009 December 3)
- Fixed many bugs in popular file format readers
4.1 (2009 October 21):
- Fixed many bugs in most file format readers
- Significantly improved confocal and HCS metadata parsing
- Improved C++ bindings
- Eliminated references to Java AWT classes in core Bio-Formats packages
- Added support for reading Flex datasets from multiple servers
- Improved OME-XML generation; generated OME-XML is now valid
- Added support for Olympus ScanR data
- Added OSGi information to JARs
- Added support for Amira Mesh files
- Added support for LI-FLIM files
- Added more informative exceptions
- Added support for various types of ICS lifetime data
- Added support for Nikon EZ-C1 TIFFs
- Added support for Maia Scientific MIAS data
4.0.1 (2009 June 1)
- Lots of bug fixes in most format readers and writers
- Added support for Analyze 7.1 files
- Added support for Nifti files
- Added support for Cellomics .c01 files
- Refactored ImageJ plugins
- Bio-Formats, the common package, and the ImageJ plugins now require Java 1.5
- Eliminated native library dependency for reading lossless JPEGs
- Changed license from GPL v3 or later to GPL v2 or later
- Updated Olympus FV1000, Zeiss LSM, Zeiss ZVI and Nikon ND2 readers to parse
ROI data
- Added option to ImageJ plugin for displaying ROIs parsed from the chosen
dataset
- Fixed BufferedImage construction for signed data and unsigned int data
4.0.0 (2009 March 3)
- Improved OME data model population for Olympus FV1000, Nikon ND2, Metamorph
STK, Leica LEI, Leica LIF, InCell 1000 and MicroManager
- Added TestNG tests for format writers
- Added option to ImageJ plugin to specify custom colors when customizing
channels
- Added ability to upgrade the ImageJ plugin from within ImageJ
- Fixed bugs in Nikon ND2, Leica LIF, BioRad PIC, TIFF, PSD, and OME-TIFF
- Fixed bugs in Data Browser and Exporter plugins
- Added support for Axon Raw Format (ARF), courtesy of Johannes Schindelin
- Added preliminary support for IPLab-Mac file format
2008 December 29
- Improved metadata support for DeltaVision, Zeiss LSM, MicroManager, and Leica
LEI
- Restructured code base/build system to be component-driven
- Added support for JPEG and JPEG-2000 codecs within TIFF, OME-TIFF and OME-XML
- Added support for 16-bit compressed Flex files
- Added support for writing JPEG-2000 files
- Added support for Minolta MRW format
- Added support for the 2008-09 release of OME-XML
- Removed dependency on JMagick
- Re-added caching support to data browser plugin
- Updated loci.formats.Codec API to be more user-friendly
- Expanded loci.formats.MetadataStore API to better represent the OME-XML model
- Improved support for Nikon NEF
- Improved support for TillVision files
- Improved ImageJ import options dialog
- Fixed bugs with Zeiss LSM files larger than 4 GB
- Fixed minor bugs in most readers
- Fixed bugs with exporting from an Image5D window
- Fixed several problems with virtual stacks in ImageJ
2008 August 30
- Fixed bugs in many file format readers
- Fixed several bugs with swapping dimensions
- Added support for Olympus CellR/APL files
- Added support for MINC MRI files
- Added support for Aperio SVS files compressed with JPEG 2000
- Added support for writing OME-XML files
- Added support for writing APNG files
- Added faster LZW codec
- Added drag and drop support to ImageJ shortcut window
- Re-integrated caching into the data browser plugin
2008 July 1
- Fixed bugs in most file format readers
- Fixed bugs in OME and OMERO download functionality
- Fixed bugs in OME server-side import
- Improved metadata storage/retrieval when uploading to and downloading from
the OME Perl server
- Improved Bio-Formats ImageJ macro extensions
- Major updates to MetadataStore API
- Updated OME-XML generation to use 2008-02 schema by default
- Addressed time and memory performance issues in many readers
- Changed license from LGPL to GPL
- Added support for the FEI file format
- Added support for uncompressed Hamamatsu Aquacosmos NAF files
- Added support for Animated PNG files
- Added several new options to Bio-Formats ImageJ plugin
- Added support for writing ICS files
2008 April 17
- Fixed bugs in Slidebook, ND2, FV1000 OIB/OIF, Perkin Elmer, TIFF, Prairie,
Openlab, Zeiss LSM, MNG, Molecular Dynamics GEL, and OME-TIFF
- Fixed bugs in OME and OMERO download functionality
- Fixed bugs in OME server-side import
- Fixed bugs in Data Browser
- Added support for downloading from OMERO 2.3 servers
- Added configuration plugin
- Updates to MetadataStore API
- Updates to OME-XML generation - 2007-06 schema used by default
- Added support for Li-Cor L2D format
- Major updates to TestNG testing framework
- Added support for writing multi-series OME-TIFF files
- Added support for writing BigTIFF files
2008 Feb 12
- Fixed bugs in QuickTime, SimplePCI and DICOM
- Fixed a bug in channel splitting logic
2008 Feb 1
Fixed bugs in Zeiss LSM, Metamorph STK, FV1000 OIB/OIF, Leica LEI, TIFF,
Zeiss ZVI, ICS, Prairie, Openlab LIFF, Gatan, DICOM, QuickTime
Fixed bug in OME-TIFF writer
Major changes to MetadataStore API
Added support for JPEG-compressed TIFF files
- Added basic support for Aperio SVS files
- JPEG2000 compression is still not supported
Improved “crop on import” functionality
Improvements to bfconvert and bfview
Improved OME-XML population for several formats
Added support for JPEG2000-compressed DICOM files
EXIF data is now parsed from TIFF files
2007 Dec 28
- Fixed bugs in Leica LEI, Leica TCS, SDT, Leica LIF,
Visitech, DICOM, Imaris 5.5 (HDF), and Slidebook readers
- Better parsing of comments in TIFF files exported from ImageJ
- Fixed problem with exporting 48-bit RGB data
- Added logic to read multi-series datasets spread across multiple files
- Improved channel merging in ImageJ - requires ImageJ 1.39l
- Support for hyperstacks and virtual stacks in ImageJ - requires ImageJ 1.39l
- Added API for reading directly from a byte array or InputStream
- Metadata key/value pairs are now stored in ImageJ’s “Info” property
- Improved OMERO download plugin - it is now much faster
- Added “open all series” option to ImageJ importer
- ND2 reader based on Nikon’s SDK now uses our own native bindings
- Fixed metadata saving bug in ImageJ
- Added sub-channel labels to ImageJ windows
- Major updates to 4D Data Browser
- Minor updates to automated testing suite
2007 Dec 1
- Updated OME plugin for ImageJ to support downloading from OMERO
- Fixed bug with floating point TIFFs
- Fixed bugs in Visitech, Zeiss LSM, Imaris 5.5 (HDF)
- Added alternate ND2 reader that uses Nikon’s native libraries
- Fixed calibration and series name settings in importer
- Added basic support for InCell 1000 datasets
2007 Nov 21
Fixed bugs in ND2, Leica LIF, DICOM, Zeiss ZVI, Zeiss LSM, FV1000 OIB,
FV1000 OIF, BMP, Evotec Flex, BioRad PIC, Slidebook, TIFF
Added new ImageJ plugins to slice stacks and do “smart” RGB merging
- Added “windowless” importer plugin
- uses import parameters from IJ_Prefs.txt, without prompting the user
Improved stack slicing and colorizing logic in importer plugin
- Added support for DICOM files compressed with lossless JPEG
- requires native libraries
Fixed bugs with signed pixel data
Added support for Imaris 5.5 (HDF) files
Added 4 channel merging to importer plugin
Added API methods for reading subimages
Major updates to the 4D Data Browser
2007 Oct 17
- Critical OME-TIFF bugfixes
- Fixed bugs in Leica LIF, Zeiss ZVI, TIFF, DICOM, and AVI readers
- Added support for JPEG-compressed ZVI images
- Added support for BigTIFF
- Added importer plugin option to open each plane in a new window
- Added MS Video 1 codec for AVI
2007 Oct 1
- Added support for compressed DICOM images
- Added support for uncompressed LIM files
- Added support for Adobe Photoshop PSD files
- Fixed bugs in DICOM, OME-TIFF, Leica LIF, Zeiss ZVI,
Visitech, PerkinElmer and Metamorph
- Improved indexed color support
- Addressed several efficiency issues
- Fixed how multiple series are handled in 4D data browser
- Added option to reorder stacks in importer plugin
- Added option to turn off autoscaling in importer plugin
- Additional metadata convenience methods
2007 Sept 11
- Major improvements to ND2 support; lossless compression now supported
- Support for indexed color images
- Added support for Simple-PCI .cxd files
- Command-line OME-XML validation
- Bugfixes in most readers, especially Zeiss ZVI, Metamorph, PerkinElmer and
Leica LEI
- Initial version of Bio-Formats macro extensions for ImageJ
2007 Aug 1
- Added support for latest version of Leica LIF
- Fixed several issues with Leica LIF, Zeiss ZVI
- Better metadata mapping for Zeiss ZVI
- Added OME-TIFF writer
- Added MetadataRetrieve API for retrieving data from a MetadataStore
- Miscellaneous bugfixes
2007 July 16
- Fixed several issues with ImageJ plugins
- Better support for Improvision and Leica TCS TIFF files
- Minor improvements to Leica LIF, ICS, QuickTime and Zeiss ZVI readers
- Added searchable metadata window to ImageJ importer
2007 July 2
- Fixed issues with ND2, Openlab LIFF and Slidebook
- Added support for Visitech XYS
- Added composite stack support to ImageJ importer
2007 June 18
- Fixed issues with ICS, ND2, MicroManager, Leica LEI, and FV1000 OIF
- Added support for large (> 2 GB) ND2 files
- Added support for new version of ND2
- Minor enhancements to ImageJ importer
- Implemented more flexible logging
- Updated automated testing framework to use TestNG
- Added package for caching images produced by Bio-Formats
2007 June 6
- Fixed OME upload/download bugs
- Fixed issues with ND2, EPS, Leica LIF, and OIF
- Added support for Khoros XV
- Minor improvements to the importer
2007 May 24
- Better Slidebook support
- Added support for Quicktime RPZA
- Better Leica LIF metadata parsing
- Added support for BioRad PIC companion files
- Added support for bzip2-compressed files
- Improved ImageJ plugins
- Native support for FITS and PGM
2007 May 2
- Added support for NRRD
- Added support for Evotec Flex (requires LuraWave Java SDK with license code)
- Added support for gzip-compressed files
- Added support for compressed QuickTime headers
- Fixed QuickTime Motion JPEG-B support
- Fixed some memory issues (repeated small array allocations)
- Fixed issues reading large (> 2 GB) files
- Removed “ignore color table” logic, and replaced with Leica-specific solution
- Added status event reporting to readers
- Added API to toggle metadata collection
- Support for multiple dimensions rasterized into channels
- Deprecated reader and writer methods that accept the ‘id’ parameter
- Deprecated IFormatWriter.save in favor of saveImage and saveBytes
- Moved dimension swapping and min/max calculation logic to delegates
- Separate GUI logic into isolated loci.formats.gui package
- Miscellaneous bugfixes and tweaks in most readers and writers
- Many other bugfixes and improvements
2007 Mar 16
- Fixed calibration bugs in importer plugin
- Enhanced metadata support for additional formats
- Fixed LSM bug
2007 Mar 7
- Added support for Micro-Manager file format
- Fixed several bugs – Leica LIF, Leica LEI, ICS, ND2, and others
- Enhanced metadata support for several formats
- Load series preview thumbnails in the background
- Better implementation of openBytes(String, int, byte[]) for most readers
- Expanded unit testing framework
2007 Feb 28
- Better series preview thumbnails
- Fixed bugs with multi-channel Leica LEI
- Fixed bugs with “ignore color tables” option in ImageJ plugin
2007 Feb 26
- Many bugfixes: Leica LEI, ICS, FV1000 OIB, OME-XML and others
- Better metadata parsing for BioRad PIC files
- Enhanced API for calculating channel minimum and maximum values
- Expanded MetadataStore API to include more semantic types
- Added thumbnails to series chooser in ImageJ plugin
- Fixed plugins that upload and download from an OME server
2007 Feb 7
- Added plugin for downloading images from OME server
- Improved HTTP import functionality
- Added metadata filtering – unreadable metadata is no longer shown
- Better metadata table for multi-series datasets
- Added support for calibration information in Gatan DM3
- Eliminated need to install JAI Image I/O Tools to read ND2 files
- Fixed ZVI bugs: metadata truncation, and other problems
- Fixed bugs in Leica LIF: incorrect calibration, first series labeling
- Fixed memory bug in Zeiss LSM
- Many bugfixes: PerkinElmer, DeltaVision, Leica LEI, LSM, ND2, and others
- IFormatReader.close(boolean) method to close files temporarily
- Replaced Compression utility class with extensible Compressor interface
- Improved testing framework to use .bioformats configuration files
2007 Jan 5
- Added support for Prairie TIFF
- Fixed bugs in Zeiss LSM, OIB, OIF, and ND2
- Improved API for writing files
- Added feature to read files over HTTP
- Fixed bugs in automated testing framework
- Miscellaneous bugfixes
2006 Dec 22
- Expanded ImageJ plugin to optionally use Image5D or View5D
- Improved support for ND2 and JPEG-2000 files
- Added automated testing framework
- Fixed bugs in Zeiss ZVI reader
- Miscellaneous bugfixes
2006 Nov 30
- Added support for ND2/JPEG-2000
- Added support for MRC
- Added support for MNG
- Improved support for floating-point images
- Fixed problem with 2-channel Leica LIF data
- Minor tweaks and bugfixes in many readers
- Improved file stitching logic
- Allow ImageJ plugin to be called from a macro
2006 Nov 2
- Bugfixes and improvements for Leica LIF, Zeiss LSM, OIF and OIB
- Colorize channels when they are split into separate windows
- Fixed a bug with 4-channel datasets
2006 Oct 31
- Added support for Imaris 5 files
- Added support for RGB ICS images
2006 Oct 30
- Added support for tiled TIFFs
- Fixed bugs in ICS reader
- Fixed importer plugin deadlock on some systems
2006 Oct 27
- Multi-series support for Slidebook
- Added support for Alicona AL3D
- Fixed plane ordering issue with FV1000 OIB
- Enhanced dimension detection in FV1000 OIF
- Added preliminary support for reading NEF images
- Added option to ignore color tables
- Fixed ImageJ GUI problems
- Fixed spatial calibration problem in ImageJ
- Fixed some lingering bugs in Zeiss ZVI support
- Fixed bugs in OME-XML reader
- Tweaked ICS floating-point logic
- Fixed memory leaks in all readers
- Better file stitching logic
2006 Oct 6
- Support for 3i SlideBook format (single series only for now)
- Support for 16-bit RGB palette TIFF
- Fixed bug preventing import of certain Metamorph STK files
- Fixed some bugs in PerkinElmer UltraView support
- Fixed some bugs in Leica LEI support
- Fixed a bug in Zeiss ZVI support
- Fixed bugs in Zeiss LSM support
- Fixed a bug causing slow identification of Leica datasets
- Fixed bugs in the channel merging logic
- Fixed memory leak for OIB format
- Better scaling of 48-bit RGB data to 24-bit RGB
- Fixed duplicate channels bug in “open each channel in a separate window”
- Fixed a bug preventing PICT import into ImageJ
- Better integration with HandleExtraFileTypes
- Better virtual stack support in Data Browser plugin
- Fixed bug in native QuickTime random access
- Keep aspect ratio for computed thumbnails
- Much faster file stitching logic
2006 Sep 27
- PerkinElmer: support for PE UltraView
- Openlab LIFF: support for Openlab v5
- Leica LEI: bugfixes, and support for multiple series
- ZVI, OIB, IPW: more robust handling of these formats (eliminated
custom OLE parsing logic in favor of Apache POI)
- OIB: better metadata parsing (but maybe still not perfect?)
- LSM: fixed a bug preventing import of certain LSMs
- Metamorph STK: fixed a bug resulting in duplicate image planes
- User interface: use of system look & feel for file chooser dialog
when available
- Better notification when JAR libraries are missing
2006 Sep 6
- Leica LIF: multiple distinct image series within a single file
- Zeiss ZVI: fixes and improvements contributed by Michel Boudinot
- Zeiss LSM: fixed bugs preventing the import of certain LSM files
- TIFF: fixed a bug preventing import of TIFFs created with Bio-Rad software